Explore how cutting-edge research at UCSF Musculoskeletal Center is transforming musculoskeletal health. From lab-grown tissue models to AI-driven solutions, innovation here is leading the charge against arthritis, osteoporosis, back pain, and more. (Video: UCSF MSK Center)
San Francisco (Jan. 22, 2025) – At the UCSF Musculoskeletal Center, innovative research is changing how we approach musculoskeletal conditions. By going beyond traditional treatments and exploring cutting-edge technology, the center is pioneering new solutions to complex health issues affecting millions.
"Our approach is holistic," said Dr. Tamara Alliston, Director of the UCSF Musculoskeletal Center. "We examine musculoskeletal conditions at every level—from the molecular signals that guide skeletal development to the broader function of joints and healthcare systems. By applying discoveries from the lab, we aim to keep people moving and healthy."
The UCSF team is redefining musculoskeletal research, bringing together experts from cell biology, engineering, data science, and surgery. Using methods like artificial intelligence, lab-grown tissue models, and high-throughput drug screens, researchers are solving tough challenges in musculoskeletal disease.
At the UCSF Musculoskeletal Center, researchers are redefining care by bridging lab discoveries with real-world solutions. Learn about their groundbreaking work tackling pain and advancing non-surgical treatments for complex conditions. (Photo: UCSF MSK Center)
"Our focus is not just on bones and muscles but on understanding how these tissues interact with each other and the rest of the body," Dr. Alliston said. "By looking at the body as a whole, we believe we can uncover new cures for diseases like arthritis, osteoporosis, back pain, and even conditions such as diabetes, delirium, and cancer."
One major shift in research is challenging outdated ideas, such as the belief that pain is always tied to structural issues. "We now know that not all pain is a result of structural damage," explained Dr. C. Benjamin Ma, department chair and a leading researcher at the center. "Not all pain requires surgery. Our team is pioneering non-surgical treatments, including finding new uses for existing medications, developing personalized exercise plans, and creating mental health interventions to reduce pain—especially after traumatic injuries."
This innovative approach to musculoskeletal research is opening new possibilities for preventing, treating, and ultimately curing many musculoskeletal diseases.
The UCSF Musculoskeletal Center is pioneering a holistic approach to musculoskeletal research, connecting disciplines like engineering, data science, and surgery to uncover new cures and keep people moving. (Photo: UCSF MSK Center)
The Musculoskeletal Center is also a hub for young scientists and trainees, fostering a collaborative environment where innovation thrives. In our video, A Skeleton for Discovery, A Skeleton for Cures, the center’s ambition and bold ideas are captured, showcasing the passion behind the team’s research efforts.
"Our goal is to train the next generation of scientists and researchers," Dr. Alliston said. "By collaborating with experts from diverse backgrounds, we can push the boundaries of what’s possible and work toward groundbreaking solutions that will change how we treat musculoskeletal diseases."
The video highlights the work and dedication of the UCSF Musculoskeletal Center’s researchers and their commitment to improving health through innovation. "It’s exciting to see how far we’ve come, and even more exciting to think about what the future holds," Dr. Ma said. "Our work is just beginning."
The Musculoskeletal Center is proud of the team’s progress, and Dr. Alliston extended her gratitude to all those involved in making this project possible. "A special thanks to everyone who contributed to this video, including Dr. Christopher Hernandez, Dr. Jeffrey Lotz, Dr. Noah Bonnheim, Dr. Anne Schafer, Dr. Edward Hsiao, Dr. Kelsey Collins, Dr. Saam Morshed, and the entire crew," Dr. Alliston said.
“With innovative research at the forefront of medical advancements, the UCSF Musculoskeletal Center is leading the charge to change the future of musculoskeletal health,” Dr. Alliston added.
A Skeleton for Discovery, A Skeleton for Cures (UCSF Musculoskeletal Center)
Videographer: Angel Cardenas, Capitol Boy Media