Jeffrey Lotz, PhD
Jeffrey Lotz, PhD
Professor
Basic Science
Parnassus Heights - Lotz Lab
513 Parnassus Ave
San Francisco CA 94143
415-502-3056
513 Parnassus Ave
San Francisco CA 94143
San Francisco CA 94143
415-502-3056
Publications
- Dudli S, Fields AJ, Samartzis D, Karppinen J, Lotz JC. Pathobiology of Modic changes. Eur Spine J. 2016 11; 25(11):3723-3734. PMID: 26914098
- Lotz JC, Fields AJ, Liebenberg EC. The role of the vertebral end plate in low back pain. Global Spine J. 2013 Jun; 3(3):153-64. PMID: 24436866
- Lotz JC. Load and the spine. How does the Goldilocks principle apply? Spine J. 2011 Jan; 11(1):44-5. PMID: 21168097
- Lotz JC. Trials of vertebroplasty for vertebral fractures. N Engl J Med. 2009 Nov 19; 361(21):2098; author reply 2099-100. PMID: 19938315
- Schultz DS, Rodriguez AG, Hansma PK, Lotz JC. Mechanical profiling of intervertebral discs. J Biomech. 2009 May 29; 42(8):1154-7. PMID: 19345361
- Lotz JC, Kim AJ. Disc regeneration: why, when, and how. Neurosurg Clin N Am. 2005 Oct; 16(4):657-63, vii. PMID: 16326289
- Lotz JC. Animal models of intervertebral disc degeneration: lessons learned. Spine (Phila Pa 1976). 2004 Dec 01; 29(23):2742-50. PMID: 15564923
- Rousseau MA, Bass EC, Lotz JC. Ventral approach to the lumbar spine of the Sprague-Dawley rat. Lab Anim (NY). 2004 Jun; 33(6):43-5. PMID: 15179439
- Walsh AJ, Lotz JC. Biological response of the intervertebral disc to dynamic loading. J Biomech. 2004 Mar; 37(3):329-37. PMID: 14757452
- Whyne CM, Hu SS, Workman KL, Lotz JC. Biphasic material properties of lytic bone metastases. Ann Biomed Eng. 2000 Sep; 28(9):1154-8. PMID: 11132199
- Lotz J, Gaertner T, Hahn M, Prellwitz W. Collagen type I metabolism after bone surgery. Arch Orthop Trauma Surg. 1999; 119(3-4):212-6. PMID: 10392522
Awards Honors
- ISSLS Prize for Low Back Pain Research
2019
ISSLS Prize for Low Back Pain Research, International Society for the Study of the Lumbar Spine, 2019
International Society for the Study of the Lumbar Spine
- Henry Farfan Award for outstanding contributions in spine related basic science research
2018
Henry Farfan Award for outstanding contributions in spine related basic science research, North American Spine Society, 2018
North American Spine Society
- Grammer/European Spine Journal Award
2017
Grammer/European Spine Journal Award, EuroSpine, 2017
EuroSpine
- ISSLS Prize for Low Back Pain Research
2017
ISSLS Prize for Low Back Pain Research, International Society for the Study of the Lumbar Spine, 2017
International Society for the Study of the Lumbar Spine
- Outstanding Paper Award
2017
Outstanding Paper Award, The Spine Journal and the North American Spine Society, 2017
The Spine Journal and the North American Spine Society
- Founding Board Member, Treasurer
2015
Founding Board Member, Treasurer, Orthopaedic Research Society Spine Section, 2015
Orthopaedic Research Society Spine Section
- Best Paper Award (co-author)
2013
Best Paper Award (co-author), International Society for the Study of the Lumbar Spine, 2013
International Society for the Study of the Lumbar Spine
- Best New Technology in Spine Care (co-inventor)
2011
Best New Technology in Spine Care (co-inventor), Orthopedics This Week, 2011
Orthopedics This Week
- Best Paper Award (co-author)
2011
Best Paper Award (co-author), Philadelphia Spine Research Society, 2011
Philadelphia Spine Research Society
- Fellow
2008
Fellow, American Institute for Medical and Biological Engineering, 2008
American Institute for Medical and Biological Engineering
- ISSLS Prize for Low Back Pain Research
2007
ISSLS Prize for Low Back Pain Research, International Society for the Study of the Lumbar Spine, 2007
International Society for the Study of the Lumbar Spine
- Deputy Editor
2005
Deputy Editor, Spine, 2005-2017
Spine
- Medtronic Sofamor Danek Best Poster Award
2001
Medtronic Sofamor Danek Best Poster Award, International Society for the Study of the Lumbar Spine, 2001
International Society for the Study of the Lumbar Spine
- Norby-Smith Award for Minimally Invasive Surgery
2000
Norby-Smith Award for Minimally Invasive Surgery, Spine Arthroplasty Society, 2000
Spine Arthroplasty Society
- Panelist for Musculoskeletal Disorders and the Workplace
1999
Panelist for Musculoskeletal Disorders and the Workplace, National Research Council, 1999
National Research Council
- Volvo Award for Low Back Pain Research
1998
Volvo Award for Low Back Pain Research, International Society for the Study of the Lumbar Spine, 1998
International Society for the Study of the Lumbar Spine
- AcroMed Award for Outstanding Spinal Research
1993
AcroMed Award for Outstanding Spinal Research, North American Spine Society, 1993
North American Spine Society
Grants & Awards
- Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
2020-05-07 - 2025-04-30
NIH U24DE029463
Role: Co-Principal Investigator
- Core Center for Musculoskeletal Biology and Medicine (Overall Application)
2019-07-01 - 2024-06-30
NIH P30AR075055
Role: Principal Investigator
- UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain
2019-09-25 - 2024-05-31
NIH U19AR076737
Role: Principal Investigator
- UCSF/UCB Joint Graduate Group in Bioengineering
1985-07-01 - 2021-06-30
NIH T32GM008155
Role: Co-Principal Investigator
- Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
2017-03-01 - 2021-02-28
NIH U24DE026914
Role: Principal Investigator
- Phenotypes of pathologic vertebral endplate degeneration
2013-08-01 - 2020-08-31
NIH R56AR063705
Role: Principal Investigator
- UCSF Core Center for Musculoskeletal Biology and Medicine
2014-07-01 - 2020-03-31
NIH P30AR066262
Role: Principal Investigator
- Non-Thermal Pulsed FUS for Treatment of Intervertebral Disc Degeneration
2017-04-01 - 2020-01-31
NIH R21EB024347
Role: Co-Principal Investigator
- Phenotypes of pathologic vertebral endplate degeneration
2013-08-01 - 2019-05-31
NIH R01AR063705
Role: Principal Investigator
- A Clinical 3D Movement Analysis System for Assessing Lower Extremity Injury Risk and Recovery in Athletes
2016-09-01 - 2018-01-31
NIH R41AR068202
Role: Principal Investigator
- University of California Tissue Regeneration Resource Center (UCTRRC)
2015-09-08 - 2016-08-31
NIH R34DE025592
Role: Principal Investigator
- Structured co-culture of stem cells and chondrocytes for spinal disc repair
2012-07-01 - 2015-04-30
NIH R21AR063357
Role: Principal Investigator
- Endplate permeability and spinal disc degeneration
2007-07-01 - 2012-06-30
NIH R01AR052811
Role: Principal Investigator
- Intervertebral disc repair with Mesenchymal Stem Cells
2005-08-20 - 2010-07-31
NIH R01AR052712
Role: Principal Investigator
- Structure/function Relationships in Annulus Fibrosus
2004-04-01 - 2010-01-31
NIH R01AR049770
Role: Principal Investigator
- Mesenchymal Stem Cell Differentiation &Mechanoplasticity
2004-07-22 - 2009-04-30
NIH R01AR049786
Role: Principal Investigator
- ANALYSIS OF INJURY AVOIDANCE STRATEGIES DURING FALLS
2000-09-20 - 2004-08-31
NIH R01AR046890
Role: Principal Investigator
- MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CTR
1977-09-15 - 2003-12-31
NIH P60AR020684
Role: Co-Investigator
- TOLERANCE OF THE INTERVERTEBRAL DISC
1998-09-30 - 2003-08-31
NIH R01AR046173
Role: Principal Investigator
- INTERVERTEBRAL DISC INJURY MECHANISMS AND TOLERANCE
1998-05-01 - 2002-03-31
NIH R01AR044179
Role: Principal Investigator
Education
| PhD | MIT/Harvard University | 09/1988 | |
| MS | Stanford University | 06/1980 | |
| BS | University of California | 06/1979 |
About Jeffrey Lotz, PhD
Jeffrey C. Lotz, PhD, holds the David S. Bradford, MD, Endowed Chair in Orthopaedic Surgery and vice chair for research. He has earned several awards for spine research, and serves as a deputy editor for the journal Spine. Dr. Lotz is the founding director of the UCSF Core Center for Musculoskeletal Biology in Medicine and the NSF Center for Disruptive Musculoskeletal Innovations, and corresponding PI for the newly-established Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration (C-DOCTOR). He has expertise in spine biomechanics, intervertebral disc biology, and tissue engineering. His laboratory work focuses on identifying mechanisms of disc degeneration, developing novel diagnostics and therapies for low back pain, and the biomechanics of spinal instrumentation.
