Faculty

Jeffrey Lotz, PhD

Jeffrey Lotz, PhD

Professor
David S. Bradford, MD, Endowed Chair in Orthopaedic Surgery

Publications

Awards and Honors

  • ISSLS Prize for Low Back Pain Research
    2023
    ISSLS Prize for Low Back Pain Research, International Society for the Study of the Lumbar Spine, 2023
    International Society for the Study of the Lumbar Spine
  • Mentorship Award
    2020
    Mentorship Award, UCSF Department of Orthopaedic Surgery, 2020
    UCSF Department of Orthopaedic Surgery
  • ISSLS Prize for Low Back Pain Research
    2019
    ISSLS Prize for Low Back Pain Research, International Society for the Study of the Lumbar Spine, 2019
    International Society for the Study of the Lumbar Spine
  • Henry Farfan Award for outstanding contributions in spine related basic science research
    2018
    Henry Farfan Award for outstanding contributions in spine related basic science research, North American Spine Society, 2018
    North American Spine Society
  • Grammer/European Spine Journal Award
    2017
    Grammer/European Spine Journal Award, EuroSpine, 2017
    EuroSpine
  • ISSLS Prize for Low Back Pain Research
    2017
    ISSLS Prize for Low Back Pain Research, International Society for the Study of the Lumbar Spine, 2017
    International Society for the Study of the Lumbar Spine
  • Outstanding Paper Award
    2017
    Outstanding Paper Award, The Spine Journal and the North American Spine Society, 2017
    The Spine Journal and the North American Spine Society
  • Founding Board Member, Treasurer
    2015
    Founding Board Member, Treasurer, Orthopaedic Research Society Spine Section, 2015
    Orthopaedic Research Society Spine Section
  • Best Paper Award (co-author)
    2013
    Best Paper Award (co-author), International Society for the Study of the Lumbar Spine, 2013
    International Society for the Study of the Lumbar Spine
  • Best Paper Award (co-author)
    2011
    Best Paper Award (co-author), Philadelphia Spine Research Society, 2011
    Philadelphia Spine Research Society
  • Best New Technology in Spine Care (co-inventor)
    2011
    Best New Technology in Spine Care (co-inventor), Orthopedics This Week, 2011
    Orthopedics This Week
  • Fellow
    2008
    Fellow, American Institute for Medical and Biological Engineering, 2008
    American Institute for Medical and Biological Engineering
  • ISSLS Prize for Low Back Pain Research
    2007
    ISSLS Prize for Low Back Pain Research, International Society for the Study of the Lumbar Spine, 2007
    International Society for the Study of the Lumbar Spine
  • Deputy Editor
    2005
    Deputy Editor, Spine, 2005-2017
    Spine
  • Medtronic Sofamor Danek Best Poster Award
    2001
    Medtronic Sofamor Danek Best Poster Award, International Society for the Study of the Lumbar Spine, 2001
    International Society for the Study of the Lumbar Spine
  • Norby-Smith Award for Minimally Invasive Surgery
    2000
    Norby-Smith Award for Minimally Invasive Surgery, Spine Arthroplasty Society, 2000
    Spine Arthroplasty Society
  • Panelist for Musculoskeletal Disorders and the Workplace
    1999
    Panelist for Musculoskeletal Disorders and the Workplace, National Research Council, 1999
    National Research Council
  • Volvo Award for Low Back Pain Research
    1998
    Volvo Award for Low Back Pain Research, International Society for the Study of the Lumbar Spine, 1998
    International Society for the Study of the Lumbar Spine
  • AcroMed Award for Outstanding Spinal Research
    1993
    AcroMed Award for Outstanding Spinal Research, North American Spine Society, 1993
    North American Spine Society

Grants

  • Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    2020-05-07 - 2025-04-30
    NIH U24DE029463
    Role: Co-Principal Investigator
  • Core Center for Musculoskeletal Biology and Medicine (Overall Application)
    2019-07-01 - 2024-06-30
    NIH P30AR075055
    Role: Principal Investigator
  • UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain
    2019-09-25 - 2024-05-31
    NIH U19AR076737
    Role: Principal Investigator
  • UCSF/UCB Joint Graduate Group in Bioengineering
    1985-07-01 - 2021-06-30
    NIH T32GM008155
    Role: Co-Principal Investigator
  • Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    2017-03-01 - 2021-02-28
    NIH U24DE026914
    Role: Principal Investigator
  • Phenotypes of pathologic vertebral endplate degeneration
    2013-08-01 - 2020-08-31
    NIH R56AR063705
    Role: Principal Investigator
  • UCSF Core Center for Musculoskeletal Biology and Medicine
    2014-07-01 - 2020-03-31
    NIH P30AR066262
    Role: Principal Investigator
  • Non-Thermal Pulsed FUS for Treatment of Intervertebral Disc Degeneration
    2017-04-01 - 2020-01-31
    NIH R21EB024347
    Role: Co-Principal Investigator
  • Phenotypes of pathologic vertebral endplate degeneration
    2013-08-01 - 2019-05-31
    NIH R01AR063705
    Role: Principal Investigator
  • A Clinical 3D Movement Analysis System for Assessing Lower Extremity Injury Risk and Recovery in Athletes
    2016-09-01 - 2018-01-31
    NIH R41AR068202
    Role: Principal Investigator
  • University of California Tissue Regeneration Resource Center (UCTRRC)
    2015-09-08 - 2016-08-31
    NIH R34DE025592
    Role: Principal Investigator
  • Structured co-culture of stem cells and chondrocytes for spinal disc repair
    2012-07-01 - 2015-04-30
    NIH R21AR063357
    Role: Principal Investigator
  • Endplate permeability and spinal disc degeneration
    2007-07-01 - 2012-06-30
    NIH R01AR052811
    Role: Principal Investigator
  • Intervertebral disc repair with Mesenchymal Stem Cells
    2005-08-20 - 2010-07-31
    NIH R01AR052712
    Role: Principal Investigator
  • Structure/function Relationships in Annulus Fibrosus
    2004-04-01 - 2010-01-31
    NIH R01AR049770
    Role: Principal Investigator
  • Mesenchymal Stem Cell Differentiation &Mechanoplasticity
    2004-07-22 - 2009-04-30
    NIH R01AR049786
    Role: Principal Investigator
  • ANALYSIS OF INJURY AVOIDANCE STRATEGIES DURING FALLS
    2000-09-20 - 2004-08-31
    NIH R01AR046890
    Role: Principal Investigator
  • MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CTR
    1977-09-15 - 2003-12-31
    NIH P60AR020684
    Role: Co-Investigator
  • TOLERANCE OF THE INTERVERTEBRAL DISC
    1998-09-30 - 2003-08-31
    NIH R01AR046173
    Role: Principal Investigator
  • INTERVERTEBRAL DISC INJURY MECHANISMS AND TOLERANCE
    1998-05-01 - 2002-03-31
    NIH R01AR044179
    Role: Principal Investigator

Education

PhD MIT/Harvard University 09/1988
MS Stanford University 06/1980
BS University of California 06/1979

About Jeffrey Lotz, PhD

Professor Jeffrey Lotz, Ph.D. is the David S. Bradford M.D. Endowed Chair in Orthopaedic Surgery and Vice Chair of Orthopaedic Research at UCSF. He has led the Orthopaedic Tissue Engineering Laboratory at UCSF since 1992, and is the principal investigator of one of the three Mechanistic Research Centers funded through the NIH Back Pain Consortium (BACPAC) Research Program (under NIH HEAL). BACPAC is a translational, patient-centered effort to address the need for effective and personalized therapies for chronic low back pain. Dr. Lotz is also co-director of two other research centers, including the NIDCR-funded Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration (C-DOCTOR, and the NSF-funded Industry/University Cooperative Research Center (CDMI). Dr. Lotz has expertise in spine biomechanics, intervertebral disc biology, and tissue engineering. His laboratory work focuses on identifying mechanisms of disc degeneration, developing novel diagnostics and therapies for low back pain, and the biomechanics of spinal instrumentation. Dr. Lotz earned a doctorate in Medical Engineering from the Harvard/MIT Division of Health Sciences and Technology, a Master's Degree in Mechanical Engineering Design from Stanford University, and a Bachelor of Science in Mechanical Engineering from UC Berkeley.

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