Rosanna Wustrack, MD

Associate Professor

Orthopaedic Oncology

Trauma & Problem Fractures

Mission Bay

1825 Fourth Street
San Francisco CA 94158

415-353-2967
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Orthopaedic Trauma Institute at Zuckerberg San Francisco General - Trauma & Problem Fractures

2540 23rd Street,
San Francisco CA 94110

4154762124
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Publications

Su F, Garcia-Lopez E, Wustrack R, Lansdown DA. Endoprosthetic Reconstruction for Proximal Humerus Tumors. Curr Rev Musculoskelet Med. 2024 Dec 04. PMID: 39630212
Tyler Kelly, Lee Jae Morse, Rosanna Wustrack, Melissa Zimel. Original Research: Proximal Tibia Hemiarthroplasty Reconstruction Following Resection of Malignant Bone Tumors in Skeletally Immature Patients. Journal of the Pediatric Orthopaedic Society of North America. 2024 Sep 1; 100118.
Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach. Clin Cancer Res. 2024 02 16; 30(4):849-864. PMID: 37703185
Pozner A, Li L, Verma SP, Wang S, Barrott JJ, Nelson ML, Yu JSE, Negri GL, Colborne S, Hughes CS, Zhu JF, Lambert SL, Carroll LS, Smith-Fry K, Stewart MG, Kannan S, Jensen B, John CM, Sikdar S, Liu H, Dang NH, Bourdage J, Li J, Vahrenkamp JM, Mortenson KL, Groundland JS, Wustrack R, Senger DL, Zemp FJ, Mahoney DJ, Gertz J, Zhang X, Lazar AJ, Hirst M, Morin GB, Nielsen TO, Shen PS, Jones KB. ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97. Nat Commun. 2024 Feb 07; 15(1):1165. PMID: 38326311
Pozner A, Verma SP, Li L, Wang S, Barrott JJ, Nelson ML, Yu JSE, Negri GL, Colborne S, Hughes CS, Zhu JF, Lambert SL, Carroll LS, Smith-Fry K, Stewart MG, Kannan S, Jensen B, Mortenson KL, John C, Sikdar S, Liu H, Dang NH, Bourdage J, Li J, Vahrenkamp JM, Groundland JS, Wustrack R, Senger DL, Zemp FJ, Mahoney DJ, Gertz J, Zhang X, Lazar AJ, Hirst M, Morin GB, Nielsen TO, Shen PS, Jones KB. ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97. bioRxiv. 2023 Oct 02. PMID: 37873234
Jackson KJ, Sullivan CD, Zimel MN, Wustrack RL, PARITY Investigators. Surgical Site Infection Is Not Associated with 1-Year Progression-Free Survival After Endoprosthetic Reconstruction for Lower-Extremity Osteosarcoma: A Secondary Analysis of PARITY Study Data. J Bone Joint Surg Am. 2023 07 19; 105(Suppl 1):49-56. PMID: 37466580
Niu I, Hsiao EC, Wustrack R, Wysolmerski JJ, Dann P, Masharani U. A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy. Calcif Tissue Int. 2023 08; 113(2):246-253. PMID: 37358786
Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MAV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities. bioRxiv. 2023 Jan 20. PMID: 36711882
Isabella Niu, Edward Hsiao, Rosanna Wustrack, John Wysolmerski, Pamela Dann, Umesh Masharani. PSAT208 A Case of Hypercalcemia From PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy. Journal of the Endocrine Society. 2022 Nov 1; 6(Suppl 1):a212-a213.
Tanaka KS, Andaya VR, Thorpe SW, Gundle KR, Hayden JB, Duong YC, Avedian RS, Mohler DG, Morse LJ, Zimel MN, O'Donnell RJ, Fang A, Randall RL, Tran TH, New C, Wustrack RL, other members of Study Group FORCE. Survival and failure modes of the Compress® spindle and expandable distal femur endoprosthesis among pediatric patients: A multi-institutional study. J Surg Oncol. 2023 Jan; 127(1):148-158. PMID: 36112398
Geiger EJ, Liu W, Srivastava DK, Bernthal NM, Weil BR, Yasui Y, Ness KK, Krull KR, Goldsby RE, Oeffinger KC, Robison LL, Dieffenbach BV, Weldon CB, Gebhardt MC, Howell R, Murphy AJ, Leisenring WM, Armstrong GT, Chow EJ, Wustrack RL. What Are Risk Factors for and Outcomes of Late Amputation After Treatment for Lower Extremity Sarcoma: A Childhood Cancer Survivor Study Report. Clin Orthop Relat Res. 2023 03 01; 481(3):526-538. PMID: 35583517
Stroud SG, Geiger EJ, Lichtensztajn DY, Goldsby RE, Cheng I, Wustrack R, Theologis AA. Survival of Patients With Primary Osseous Malignancies of the Mobile Spine Is Associated With Access to "Standard Treatment" Protocols. J Am Acad Orthop Surg. 2022 Sep 01; 30(17):841-850. PMID: 35507547
Andrew S. Jack, Christopher Witiw, Aaron Hockley, Charlotte J. Huie, Rosanna Wustrack, Line G. Jacques. Malignant triton tumor in the setting of segmental neurofibromatosis: A rare case report and review of the literature. Interdisciplinary Neurosurgery. 2021 Jun 1; 24:101073.
Wustrack RL, Shao E, Sheridan J, Zimel M, Cho SJ, Horvai AE, Luong D, Kwek SS, Fong L, Okimoto RA. Tumor morphology and location associate with immune cell composition in pleomorphic sarcoma. Cancer Immunol Immunother. 2021 Oct; 70(10):3031-3040. PMID: 33864502
Michelle J. Hall, Rosanna L. Wustrack, Donald R. Cummings, Richard I. Welling, Mary K. Kaleta, Kevin D. Koenig, Jennifer C. Laine, Sara J. Morgan. Innovations in Pediatric Prosthetics. Journal of the Pediatric Orthopaedic Society of North America. 2021 Feb 1; 3(1):221.
Guinn JMV, Mayer RR, Li B, Dang ABC, Dang A, Wustrack R, Chou D. En bloc excision of sacroiliac chondrosarcoma aided by 3D laser printed modeling and stereotactic navigation. J Clin Neurosci. 2021 Mar; 85:64-66. PMID: 33581792
Fang AS, Morse LJ, Wustrack R, Huber R, Pan M. Complete Regression of Rhabdomyosarcoma in an Adult Secondary to Postoperative Wound Infection Following Limb Salvage Surgery: A Case Report. Perm J. 2020 12; 25:1. PMID: 33635775
W.S. Chen, M. Lometti, R.L. Wustrack, M.N. Zimel, R.J. O'Donnell, A.E. Horvai, S.J. Cho, R.A. Okimoto, T.M. Jahan, A.R. Gottschalk, S.E. Braunstein. Intraoperative Radiotherapy Without External Beam Radiotherapy in the Management of Primary Soft Tissue Sarcomas of the Extremities. International Journal of Radiation Oncology • Biology • Physics. 2020 Nov 1; 108(3):e5.
J. Chew, S.A. Lloyd, R.A. Okimoto, A. Sabnis, E. Nakakura, C. Corvera, M.N. Zimel, A.E. Horvai, S.J. Cho, R.L. Wustrack, A.R. Gottschalk, R.J. O'Donnell, T.M. Jahan, S.E. Braunstein. Outcomes of Elderly Patients with Soft Tissue Sarcoma of the Extremities. International Journal of Radiation Oncology • Biology • Physics. 2020 Nov 1; 108(3):e6.
Wustrack R, Rao SS, Morris CD. Musculoskeletal Effects of Cancer and Cancer Treatment. J Am Acad Orthop Surg. 2020 Aug 15; 28(16):e716-e728. PMID: 32769720
Zara Butte, Kara Tanaka, Veronica Andaya, Melissa Zimel, Richard J O’Donnell, Rosanna Wustrack. Risk of endoprosthetic infection and impact of health-related quality of life in patients with osteosarcoma and giant cell tumor of bone; a retrospective case-control study. Annals of Joint. 2020 Jul 1; 5(0):27-27.
Penumarthy NL, Goldsby RE, Shiboski SC, Wustrack R, Murphy P, Winestone LE. Insurance impacts survival for children, adolescents, and young adults with bone and soft tissue sarcomas. Cancer Med. 2020 02; 9(3):951-958. PMID: 31838786
Guy Ledergor, Elizabeth McCarthy, Nina Shah, Sandy Wong, Hewitt Chang, Frances Fan, Evans Shao, Lissa Gray, Alexander Cheung, Serena Kwek, Sophia Bylsma, Samuel Del Favero, Rosanna Wustrack, Matthew Spitzer, Jeffrey Wolf, Thomas Martin, Jimmie Ye, Lawrence Fong. Single cell Dissection of Resistance to anti-BCMA CAR-T cell Therapy. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e25-e26.
Heunis JC, Cheah JW, Sabnis AJ, Wustrack RL. Use of three-dimensional printing and intraoperative navigation in the surgical resection of metastatic acetabular osteosarcoma. BMJ Case Rep. 2019 Sep 30; 12(9). PMID: 31570349
Musa B. Zaid, Rosanna L. Wustrack, Matthew Garibaldi, Erik Geiger, Veronica Andaya, Richard J. O'Donnell. Prospective study of percutaneous bone-anchored implants in transfemoral amputees: Brain-machine platform technology for external prosthetic control and feedback. 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER). 2019 Mar 1; 13-16.
Pandya NK, Wustrack R, Metz L, Ward D. Current Concepts in Orthopaedic Care Disparities. J Am Acad Orthop Surg. 2018 Dec 01; 26(23):823-832. PMID: 30180094
Shaw JD, Miller S, Plourde A, Shaw DL, Wustrack R, Hansen EN. Methylene Blue-Guided Debridement as an Intraoperative Adjunct for the Surgical Treatment of Periprosthetic Joint Infection. J Arthroplasty. 2017 12; 32(12):3718-3723. PMID: 28811108
Morris CD, Wustrack RL, Levin AS. Limb-Salvage Options in Growing Children with Malignant Bone Tumors of the Lower Extremity: A Critical Analysis Review. JBJS Rev. 2017 07; 5(7):e7. PMID: 28742715
Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, Bhatia S, Nakamura JL. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors. Clin Cancer Res. 2017 Apr 01; 23(7):1852-1861. PMID: 27683180
Wustrack R, Cooper K, Weber K. Molecular Markers in Bone and Soft-Tissue Tumors. JBJS Rev. 2016 08 30; 4(8). PMID: 27603273
Lansdown DA, Whitaker A, Wustrack R, Sawyer A, Hansen EN. A Resident-led Initiative Improves Screening and Treatment for Vitamin D Deficiency in Patients with Hip Fractures. Clin Orthop Relat Res. 2017 Jan; 475(1):264-270. PMID: 27549989
Corinna Clio Zygourakis, Victoria Valencia, Chris Moriates, Christy Boscardin, Sereina Catschegn, Andrew Goldberg, Kevin Bozic, Kent Soo Hoo, Rosanna Wustrack, Lawrence H. Pitts, Adams Dudley, Ralph Gonzales, Michael T. Lawton. 152 A Prospective Controlled Trial of the Effect of Surgeon Cost Scorecards on Operating Room Surgical Cost Reduction. Neurosurgery. 2016 Aug 1; 63:161-162.
Goldman LH, Morse LJ, O'Donnell RJ, Wustrack RL. How Often Does Spindle Failure Occur in Compressive Osseointegration Endoprostheses for Oncologic Reconstruction? Clin Orthop Relat Res. 2016 Jul; 474(7):1714-23. PMID: 27106130
Katharine N. Legaspi, Timothy V. Galan, Rosanna L. Wustrack, Richard J. O’Donnell. Total femoral and proximal tibial compressive osseointegration. Current Orthopaedic Practice. 2016 Jan 1; 27(2):231-235.
Christopher L. Tinkle, Stuart Y. Tsuji, Vivian Weinberg, Rosanna Wustrack, Steve E. Braunstein, Daphne A. Haas-Kogan, Steven G. DuBois, Andrew Horvai, Thierry Jahan, Richard J. O’Donnell, Alexander R. Gottschalk. Intraoperative radiotherapy and limb-sparing surgery in the treatment of primary, non-metastatic extremity soft tissue sarcoma. Journal of Radiation Oncology. 2015 Sep 1; 4(3):299-307.
Tinkle CL, Weinberg V, Braunstein SE, Wustrack R, Horvai A, Jahan T, O'Donnell RJ, Gottschalk AR. Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma. Sarcoma. 2015; 2015:913565. PMID: 26346118
Wong T, Goldsby RE, Wustrack R, Cash T, Isakoff MS, DuBois SG. Clinical features and outcomes of infants with Ewing sarcoma under 12 months of age. Pediatr Blood Cancer. 2015 Nov; 62(11):1947-51. PMID: 26173989
Carolyn J. Vaughn, Merisa L. Piper, Rosanna Wustrack, Hani Sbitany. Abstract P13. Plastic & Reconstructive Surgery. 2015 May 1; 135(5S):133-134.
Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE. Secondary malignant neoplasms among children, adolescents, and young adults with osteosarcoma. Cancer. 2014 Dec 15; 120(24):3987-93. PMID: 25116228
Napoli N, Schwartz AV, Palermo L, Jin JJ, Wustrack R, Cauley JA, Ensrud KE, Kelly M, Black DM. Risk factors for subtrochanteric and diaphyseal fractures: the study of osteoporotic fractures. J Clin Endocrinol Metab. 2013 Feb; 98(2):659-67. PMID: 23345099
Metz LN, Wustrack R, Lovell AF, Sawyer AJ. Infectious, inflammatory, and metabolic diseases affecting the athlete's spine. Clin Sports Med. 2012 Jul; 31(3):535-67. PMID: 22658001
Napoli N, Jin J, Peters K, Wustrack R, Burch S, Chau A, Cauley J, Ensrud K, Kelly M, Black DM. Are women with thicker cortices in the femoral shaft at higher risk of subtrochanteric/diaphyseal fractures? The study of osteoporotic fractures. J Clin Endocrinol Metab. 2012 Jul; 97(7):2414-22. PMID: 22547423
Jeffrey MacLean, Rosanna Wustrack, Utku Kandemir. Compartment Syndrome of Thigh. Techniques in Orthopaedics. 2012 Mar 1; 27(1):47-52.
Jeffrey MacLean, Rosanna Wustrack, Utku Kandemir. Gluteal Compartment Syndrome. Techniques in Orthopaedics. 2012 Mar 1; 27(1):43-46.
Pedtke AC, Wustrack RL, Fang AS, Grimer RJ, O'Donnell RJ. Aseptic failure: how does the Compress(®) implant compare to cemented stems? Clin Orthop Relat Res. 2012 Mar; 470(3):735-42. PMID: 22045069
Wustrack R, Seeman E, Bucci-Rechtweg C, Burch S, Palermo L, Black DM. Predictors of new and severe vertebral fractures: results from the HORIZON Pivotal Fracture Trial. Osteoporos Int. 2012 Jan; 23(1):53-8. PMID: 21691843
Gomberg SJ, Wustrack RL, Napoli N, Arnaud CD, Black DM. Teriparatide, vitamin D, and calcium healed bilateral subtrochanteric stress fractures in a postmenopausal woman with a 13-year history of continuous alendronate therapy. J Clin Endocrinol Metab. 2011 Jun; 96(6):1627-32. PMID: 21430030
R. Wustrack, E. Seeman, C. Bucci-Rechtweg, L. Palermo, D. Black. Impact of zoledronic acid on severe vertebral fractures: Results from horizon-pivotal fracture trial. Bone. 2010 Jun 1; 47:s194-s195.
Goldfarb CA, Wustrack R, Pratt JA, Mender A, Manske PR. Thumb function and appearance in thrombocytopenia: absent radius syndrome. J Hand Surg Am. 2007 Feb; 32(2):157-61. PMID: 17275588

Awards and Honors

Muriel Steele Society Honor Roll
2021
Muriel Steele Society Honor Roll, UCSF Muriel Steele Society, 2021-2022
UCSF Muriel Steele Society
Compassionate Physician Award
2020
Compassionate Physician Award, UCSF Department of Orthopedic Surgery, 2020
UCSF Department of Orthopedic Surgery
Exceptional Physician Award
2020
Exceptional Physician Award, UCSF Health, 2020
UCSF Health
Muriel Steele Society Honor Roll
2020
Muriel Steele Society Honor Roll, UCSF Muriel Steele Society, 2020
UCSF Muriel Steele Society
Mentored Research Award
2019
Mentored Research Award, Musculoskeletal Research Society, 2019-2020
Musculoskeletal Research Society
Identifying and enhancing the host immune response in adult soft tissue sarcoma
2018
Identifying and enhancing the host immune response in adult soft tissue sarcoma, UCSF RAP Grant Program, 2018-2019
UCSF RAP Grant Program
Excellence in Teaching Award
2018
Excellence in Teaching Award, UCSF Academy of Medical Educators, 2018
UCSF Academy of Medical Educators
James O. Johnston Resident Teaching Award
2016
James O. Johnston Resident Teaching Award, UCSF Department of Orthopedic Surgery, 2016
UCSF Department of Orthopedic Surgery
Mauer Chief Resident of the Year
2012
Mauer Chief Resident of the Year, UCSF Department of Orthopedic Surgery, 2012
UCSF Department of Orthopedic Surgery

Grants

Transfemoral Amputee Osseointegration Study
2017-09-30 - 2022-10-01
Department of Defense, United States Army Medical Research and Materiel Command W81XWH-17-2-0060, USAMRMC-BA160465
Role: Co-Investigator

An Osseo-Neural Transtibial Prosthesis with Efferent-Afferent Neural Control
2019-04-15 - 2022-04-14
Department of Defense, United States Army Medical Research and Materiel Command W81XWH-19-1-0151
Role: Co-Investigator

Identifying and enhancing the host immune response in adult soft tissue sarcoma
2019-07-01 - 2021-06-30
Musculoskeletal Tumor Society
Role: Principal Investigator

Education

Certificate, Diversity, Equity, and Inclusion Champion Training	University of California, San Francisco	2018
Certificate, Advanced Training in Clinical Research	University of California, San Francisco	2014
Fellowship	Memorial Sloan Kettering Cancer Center	2013
Residency	University of California San Francisco Department of Orthopedic Surgery	2012
MD	Washington University in St. Louis Medical School	2006
BA	Yale University	1999

Videos

Meet the Doctor: Rosanna Wustrack, MD

About Rosanna Wustrack, MD

Dr. Rosanna Wustrack is an orthopedic surgeon who specializes in the surgical diagnosis and treatment of musculoskeletal tumors and fragility fractures, and she is Chief of the Orthopaedic Oncology Service.

Her research focuses on immunotherapy for sarcomas, functional outcomes in cancer patients, osseointegration and optimizing treatment for metastatic disease. She also is interested in global health and osteoporosis in cancer survivors.

Dr. Wustrack received an undergraduate degree from Yale University before earning a medical degree from Washington University School of Medicine in St. Louis. She completed an internship and residency in orthopedic surgery at UCSF. Subsequently, she completed fellowship training in musculoskeletal oncology at Memorial Sloan Kettering Cancer Center in New York.

Additionally, Dr. Wustrack is a member of the UCSF Sarcoma Center, a multidisciplinary team of sarcoma specialists who provide patients with the most precise diagnostic tools, novel surgical and reconstructive techniques, and promising new therapies. Learn more: https://sarcoma.ucsf.edu/.

Faculty