Chelsea Bahney, PhD

Chelsea Bahney, PhD

Chelsea Bahney, PhD

Associate Professor

Basic Science

Orthopaedic Trauma Institute - Bahney Lab

2550 23rd Street
San Francisco CA 94110

628-206-8812

Orthopaedic Trauma Institute at Zuckerberg San Francisco General

2550 23rd Street
San Francisco CA 94110

628-206-8812
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Publications

Matthew D. Crawford, Justin Hellwinkel, Zachary Aman, Ramesses Akamefula, Thomas Singleton, Chelsea Bahney, Robert LaPrade. Revisiting Arnoczky: Measuring the Microvascular Anatomy of Young Adult Menisci. Arthroscopy The Journal of Arthroscopic and Related Surgery. 2021 Jan 1; 37(1):e32. PMID:

Gresham RCH, Bahney CS, Leach JK. Growth factor delivery using extracellular matrix-mimicking substrates for musculoskeletal tissue engineering and repair. Bioact Mater. 2021 Jul; 6(7):1945-1956. PMID: 33426369

Crawford MD, Hellwinkel JE, Aman Z, Akamefula R, Singleton JT, Bahney C, LaPrade RF. Microvascular Anatomy and Intrinsic Gene Expression of Menisci From Young Adults. Am J Sports Med. 2020 11; 48(13):3147-3153. PMID: 33044839

Hellwinkel JE, Miclau T, Provencher MT, Bahney CS, Working ZM. The Life of a Fracture: Biologic Progression, Healing Gone Awry, and Evaluation of Union. JBJS Rev. 2020 08; 8(8):e1900221. PMID: 32796195

Working ZM, Morris ER, Chang JC, Coghlan RF, Johnstone B, Miclau T, Horton WA, Bahney CS. A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing. J Orthop Res. 2021 01; 39(1):53-62. PMID: 32533783

Liebig BE, Kisiday JD, Bahney CS, Ehrhart NP, Goodrich LR. The platelet-rich plasma and mesenchymal stem cell milieu: A review of therapeutic effects on bone healing. J Orthop Res. 2020 12; 38(12):2539-2550. PMID: 32589800

Michael Mullen, Chelsea Bahney, Sudheer Ravuri, Johnny Huard, Nicole Ehrhart. Exosome Production and Regenerative Potential is Influenced by Mechanical Stimulus and Cell Origin. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. PMID:

Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS. Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma. Sci Rep. 2019 08 21; 9(1):12199. PMID: 31434912

Chelsea S. Bahney. Challenging the paradigms in the classroom: the fate of chondrocytes. The FASEB Journal. 2019 Apr 1; 33(S1):80.2-80.2. PMID:

Lin MC, Hu D, Marmor M, Herfat ST, Bahney CS, Maharbiz MM. Smart bone plates can monitor fracture healing. Sci Rep. 2019 02 14; 9(1):2122. PMID: 30765721

Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, Miclau T, Marcucio RS, Hankenson KD. Cellular biology of fracture healing. J Orthop Res. 2019 01; 37(1):35-50. PMID: 30370699

Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA. A degradation fragment of type X collagen is a real-time marker for bone growth velocity. . 2018 Sep 11. PMID:

Bragdon BC, Bahney CS. Origin of Reparative Stem Cells in Fracture Healing. Curr Osteoporos Rep. 2018 08; 16(4):490-503. PMID: 29959723

Wong SA, Rivera KO, Miclau T, Alsberg E, Marcucio RS, Bahney CS. Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering. Front Bioeng Biotechnol. 2018; 6:58. PMID: 29868574

Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA. A degradation fragment of type X collagen is a real-time marker for bone growth velocity. Sci Transl Med. 2017 Dec 06; 9(419). PMID: 29212713

Lin MC, Hu D, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. Using impedance to track fracture healing rates in mice in vivo: A pilot study. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:1724-1727. PMID: 29060219

Lin MC, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. New opportunities for fracture healing detection: Impedance spectroscopy measurements correlate to tissue composition in fractures. J Orthop Res. 2017 12; 35(12):2620-2629. PMID: 28383765

MacBarb RF, Lindsey DP, Bahney CS, Woods SA, Wolfe ML, Yerby SA. Fortifying the Bone-Implant Interface Part 1: An In Vitro Evaluation of 3D-Printed and TPS Porous Surfaces. Int J Spine Surg. 2017; 11:15. PMID: 28765799

Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T. Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing? Front Cell Dev Biol. 2017; 5:45. PMID: 28523266

Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 01 15; 144(2):221-234. PMID: 28096214

Bahney CS, Bruder SP, Cain JD, Keyak JH, Killian ML, Shapiro IM, Jones LC. Accelerating the pace of discovery in orthopaedic research: A vision toward team science. J Orthop Res. 2016 10; 34(10):1673-1679. PMID: 27219218

Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC. Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Tissue Eng Part A. 2016 Mar; 22(5-6):427-35. PMID: 26830207

Giannoudis PV, Hak D, Sanders D, Donohoe E, Tosounidis T, Bahney C. Inflammation, Bone Healing, and Anti-Inflammatory Drugs: An Update. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S6-9. PMID: 26584270

Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T. Stem Cell Therapies in Orthopaedic Trauma. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S24-7. PMID: 26584262

Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C. Tissue engineering strategies for promoting vascularized bone regeneration. Bone. 2016 Feb; 83:197-209. PMID: 26608518

Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S. The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells. Acta Biomater. 2015 May; 18:100-11. PMID: 25735800

Bahney, CS; Hu, DP; Miclau, T; Marcucio, RS. Review Article. The multifaceted role of the vasculature in endochondral fracture repair. 2015. PMID:

Bahney CS, Hu DP, Miclau T, Marcucio RS. The multifaceted role of the vasculature in endochondral fracture repair. Front Endocrinol (Lausanne). 2015; 6:4. PMID: 25699016

Lin MC, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. Impedance spectroscopy to monitor fracture healing. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:5138-41. PMID: 26737448

Chelsea Bahney, Amit Jha, Diane Hu, Aaron Taylor, Hayley Britz, Benedikt Hallgrimsson, Ted Miclau, Ralph Marcucio. Endochondral bone tissue engineering: using cartilage to drive vascularized bone regeneration (87.6). The FASEB Journal. 2014 Apr 1; 28. PMID:

Chelsea Bahney, Aaron Taylor, Ali Sadat, Kathryn Tormos, Ted Miclau, Emin Maltepe, Ralph Marcucio. Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6). The FASEB Journal. 2014 Apr 1; 28. PMID:

Chelsea Bahney, Diane Hu, Federico Ferro, Aaron Taylor, Ted Miclau, Ralph Marcucio. Transdifferentiation of hypertrophic chondrocytes during endochondral bone repair by activation of pluripotent stem cell programs (216.1). The FASEB Journal. 2014 Apr 1; 28. PMID:

C.S. Bahney, R.S. Marcucio. 9 Cartilage grafts for bone repair and regeneration. Bone Substitute Biomaterials. 2014 Jan 1; 219-243. PMID:

K.K. Mallick, S. Sprio, M. Sandri, M. Iafisco, A. Ruffini, S. Minardi, A. Tampieri, P. Bhattacharya, G.H. van Lenthe, E.B. Hunziker, T.J. Blokhuis, V. Guarino, M.G. Raucci, A. Ronca, V. Cirillo, L. Ambrosio, K.K. Mallick, J. Winnett, A. Bansiddhi, D.C. Dunand, G.C. Wang, Z.F. Lu, H. Zreiqat, C.S. Bahney, R.S. Marcucio, J. Venkatesan, S.K. Kim, L. Grøndahl, C.S. Goonasekera, K.S. Jack, S.A. Clarke, P. Walsh. Contributor contact details. Bone Substitute Biomaterials. 2014 Jan 1; xi-xiii. PMID:

Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS. Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation. J Bone Miner Res. 2014; 29(5):1269-82. PMID: 24259230

Yu YY, Bahney C, Hu D, Marcucio RS, Miclau T. Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects. J Vis Exp. 2012 Apr 11; (62). PMID: 22525683

Chelsea Shields Bahney, Diane Hu, Theodore Miclau, Ralph Marcucio. Tissue engineering bone by recapitulating developmental and repair programs offers improved biological outcomes. The FASEB Journal. 2012 Apr 1; 26:917.7-917.7. PMID:

Bahney CS, Miclau T. Therapeutic potential of stem cells in orthopedics. Indian J Orthop. 2012 Jan; 46(1):4-9. PMID: 22345800

Bahney CS, Lujan TJ, Hsu CW, Bottlang M, West JL, Johnstone B. Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels. Eur Cell Mater. 2011 Jul 15; 22:43-55; discussion 55. PMID: 21761391

Bahney CS, Hsu CW, Yoo JU, West JL, Johnstone B. A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells. FASEB J. 2011 May; 25(5):1486-96. PMID: 21282205

Lujan TJ, Wirtz KM, Bahney CS, Madey SM, Johnstone B, Bottlang M. A novel bioreactor for the dynamic stimulation and mechanical evaluation of multiple tissue-engineered constructs. Tissue Eng Part C Methods. 2011 Mar; 17(3):367-74. PMID: 20950252

Buxton AN, Bahney CS, Yoo JU, Johnstone B. Temporal exposure to chondrogenic factors modulates human mesenchymal stem cell chondrogenesis in hydrogels. Tissue Eng Part A. 2011 Feb; 17(3-4):371-80. PMID: 20799905

Working ZM, Peterson D, Lawson M, O'Hara K, Coghlan R, Provencher MT, Friess DM, Johnstone B, Miclau T, Bahney CS. Collagen X Longitudinal Fracture Biomarker Suggests Staged Fixation in Tibial Plateau Fractures Delays Rate of Endochondral Repair. J Orthop Trauma. 2022 Feb 01; 36(Suppl 2):S32-S39. PMID: 35061649

Wong SA, Hu DP, Slocum J, Lam C, Nguyen M, Miclau T, Marcucio RS, Bahney CS. Chondrocyte-to-osteoblast transformation in mandibular fracture repair. J Orthop Res. 2021 08; 39(8):1622-1632. PMID: 33140859

Stewart CC, O'Hara NN, Bzovsky S, Bahney CS, Sprague S, Slobogean GP, Vita-Shock Investigators. Bone turnover markers as surrogates of fracture healing after intramedullary fixation of tibia and femur fractures. Bone Joint Res. 2022 04; 11(4):239-250. PMID: 35442058

Erickson CB, Hill R, Pascablo D, Kazakia G, Hansen K, Bahney C. A timeseries analysis of the fracture callus extracellular matrix proteome during bone fracture healing. J Life Sci (Westlake Village). 2021 Dec; 3(4):1-30. PMID: 35765657

Kaitlyn Whitney, Heidi Kloser, Charles Huard, Chelsea Bahney, Matthew Provencher, Jonathan Godin, Johnny Huard, Robert Waltz. Poster 217: Local and Systemic Comparison of Senescent Profiles in Acute Knee Injury. Orthopaedic Journal of Sports Medicine. 2022 Jul 1; 10(7_suppl5):2325967121s00778. PMID:

Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C, Philippon MJ, Huard J. The effects of losartan or angiotensin II receptor antagonists on cartilage: a systematic review. Osteoarthritis Cartilage. 2022 Dec 28. PMID: 36586717

Li J, Sudiwala S, Berthoin L, Mohabbat S, Gaylord EA, Sinada H, Cruz Pacheco N, Chang JC, Jeon O, Lombaert IMA, May AJ, Alsberg E, Bahney CS, Knox SM. Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel. Sci Adv. 2022 Dec 21; 8(51):eadc8753. PMID: 36542703

Miclau K, Hambright WS, Huard J, Stoddart MJ, Bahney CS. Cellular expansion of MSCs: Shifting the regenerative potential. Aging Cell. 2023 01; 22(1):e13759. PMID: 36536521

Marcucio RS, Miclau T, Bahney CS. A Shifting Paradigm: Transformation of Cartilage to Bone during Bone Repair. J Dent Res. 2023 Jan; 102(1):13-20. PMID: 36303415

Mullen M, Williams K, LaRocca T, Duke V, Hambright WS, Ravuri SK, Bahney CS, Ehrhart N, Huard J. Mechanical strain drives exosome production, function, and miRNA cargo in C2C12 muscle progenitor cells. J Orthop Res. 2022 Oct 17. PMID: 36250617

Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C, Philippon MJ, Huard J. The effects of fisetin on bone and cartilage: A systematic review. Pharmacol Res. 2022 11; 185:106504. PMID: 36243333

Nelson AL, Fontana G, Miclau E, Rongstad M, Murphy W, Huard J, Ehrhart N, Bahney C. Therapeutic approaches to activate the canonical Wnt pathway for bone regeneration. J Tissue Eng Regen Med. 2022 11; 16(11):961-976. PMID: 36112528

Fukase N, Duke VR, Lin MC, Stake IK, Huard M, Huard J, Marmor MT, Maharbiz MM, Ehrhart NP, Bahney CS, Herfat ST. Wireless Measurements Using Electrical Impedance Spectroscopy to Monitor Fracture Healing. Sensors (Basel). 2022 Aug 19; 22(16). PMID: 36016004

Haffner-Luntzer M, Foertsch S, Fischer V, Prystaz K, Tschaffon M, M?dinger Y, Bahney CS, Marcucio RS, Miclau T, Ignatius A, Reber SO. Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via �-AR signaling. Proc Natl Acad Sci U S A. 2019 04 23; 116(17):8615-8622. PMID: 30948630

Rivera KO, Russo F, Boileau RM, Tomlinson RE, Miclau T, Marcucio RS, Desai TA, Bahney CS. Local injections of �-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion. Sci Rep. 2020 12 17; 10(1):22241. PMID: 33335129

Haffner-Luntzer M, Weber B, Morioka K, Lackner I, Fischer V, Bahney C, Ignatius A, Kalbitz M, Marcucio R, Miclau T. Altered early immune response after fracture and traumatic brain injury. Front Immunol. 2023; 14:1074207. PMID: 36761764

Fok SW, Gresham RCH, Ryan W, Osipov B, Bahney C, Leach JK. Macromolecular crowding and decellularization method increase the growth factor binding potential of cell-secreted extracellular matrices. Front Bioeng Biotechnol. 2023; 11:1091157. PMID: 36756385

Yan-yiu Yu, Chelsea Bahney, Diane Hu, Ralph S. Marcucio, Theodore Miclau, III. Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects. Journal of Visualized Experiments. 2012 Apr 11; (62). PMID:

Hellwinkel JE, Working ZM, Certain L, Garc?a AJ, Wenke JC, Bahney CS. The intersection of fracture healing and infection: Orthopaedics research society workshop 2021. J Orthop Res. 2022 03; 40(3):541-552. PMID: 35076097

Yamaura K, Sather NA, Metlushko A, Nishimura H, Pavlovic RZ, Hambright S, Ravuri SK, Philippon MJ, Stupp SI, Bahney CS, Huard J. Sustained-release losartan from peptide nanofibers promotes chondrogenesis. Front Bioeng Biotechnol. 2023; 11:1122456. PMID: 36814717

Hambright WS, Mu X, Gao X, Guo P, Kawakami Y, Mitchell J, Mullen M, Nelson AL, Bahney C, Nishimura H, Hellwinkel J, Eck A, Huard J. The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24-/- Progeria Mouse Model. J Osteoporos. 2023; 2023:5572754. PMID: 36875869

Grants & Awards

Bimodal therapeutic application of LIF for regulating chondrogenic fate
2017-07-01 - 2018-07-01
UCSF Center for Center for Musculoskeletal Biology and Medicine
Role: PI

Promoting vascularized bone regeneration with endochondral cartilage grafts
2015-06-01 - 2018-01-01
AO Foundation Start Up Grant
Role: PI

A Murine Model of Polytrauma: Understanding the molecular basis of accelerated bone repair with concomitant traumatic brain injury.
2015-05-01 - 2017-12-31
NIH R21
Role: Co-Investigator

Innervation during fracture repair: exploring functional mechanisms and innovative therapeutic repair strategies.
2015-10-01 - 2017-10-01
Foundation of Orthopaedic Trauma
Role: PI

Development of a Novel Impedance Sensor to Monitor Fracture Healing
2014-08-01 - 2017-08-01
NSF Center for Disruptive Musculoskeletal Innovation
Role: Co-PI

OsteoNova: Tissue Engineering Approach to Translating Endochondral Bone Regeneration
2015-03-01 - 2017-06-30
UCSF Catalyst
Role: PI

Tissue engineering application of endochondral ossification for bone regeneration
2012-03-01 - 2015-02-28
NIH F32AR062469
Role: Principal Investigator

Therapeutic Application of Painless Nerve Growth Factor to Accelerate Endochondral Fracture Repair
2021-09-21 - 2026-07-31
NIH R01AR077761
Role: Principal Investigator

Education

	Post-Doctoral Fellowship	University of California, San Francisco	04/2014
	PhD	Oregon Health & Science University	08/2010
		Valleylab (now Medtronic)	08/2005
	BS	University of Colorado	06/2001

About Chelsea Bahney, PhD

The overall goal of my research is to develop novel therapies for the treatment of musculoskeletal diseases and injuries. Specifically, I believe we can drive improved tissue regeneration by recapitulating the normal sequences of development and repair. To accomplish this “Developmental Engineering” approach our laboratory utilizes a cross-disciplinary tools combining biologically modified synthetic polymers, stem cell biology, and murine models of orthopaedic injuries. The long-term goal of our research is to solve problems that will have a direct and significant impact on human health.

Current Projects:

(1) Tissue engineering strategies to promote endochondral bone regeneration

(2) Transdifferentiation of cartilage to bone during fracture repair and osteoarthritis

(3) The role of the nerve in fracture repair

(4) Polytraumatic Injuries: How brain trauma influences fracture healing

(5) Impedance sensors to monitor fracture healing

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