Alexis Dang, MD
|M.D.||University of California, San Francisco||2004|
- Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S. Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study. J Orthop Res. 2016 Oct; 34(10):1780-1789. PMID: 26895619
- Onur T, Dang A. Reduction of environmental temperature mitigates local anesthetic cytotoxicity in bovine articular chondrocytes. J Sports Sci Med. 2014 Sep; 13(3):516-21. PMID: 25177176
- Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014; 51(7):1109-18. PMID: 25436890
- Onur TS, Sitron CS, Dang A. Co-administration of hyaluronic acid with local anaesthetics shows lower cytotoxicity than local anaesthetic treatment alone in bovine articular chondrocytes. Bone Joint Res. 2013; 2(12):270-5. PMID: 24333946
- Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB. Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis. J Orthop Res. 2014 Feb; 32(2):318-23. PMID: 24167068
- Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC. Cytotoxicity of local anesthetics on human mesenchymal stem cells. J Bone Joint Surg Am. 2013 Jan 16; 95(2):132-7. PMID: 23324960
- Dang AB, McCarthy MB, Dang AB, Chowaniec DM, Mazzocca AD. Effects of adding epinephrine to arthroscopic irrigation fluid on cultured chondrocyte survival in vitro. Arthroscopy. 2011 Aug; 27(8):1118-22. PMID: 21708446
- Dang AC, Kim HT. Chondrocyte apoptosis after simulated intraarticular fracture: a comparison of histologic detection methods. Clin Orthop Relat Res. 2009 Jul; 467(7):1877-84. PMID: 19363641
- Dang AB, Tay BK, Kim HT, Nauth A, Alfonso-Jaume MA, Lovett DH. Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis. Spine (Phila Pa 1976). 2008 Aug 01; 33(17):E576-9. PMID: 18670324
- Kim HT, Teng MS, Dang AC. Chondrocyte apoptosis: implications for osteochondral allograft transplantation. Clin Orthop Relat Res. 2008 Aug; 466(8):1819-25. PMID: 18506558
- Belzberg H, Shoemaker WC, Wo CC, Nicholls TP, Dang AB, Zelman V, Gruen JP, Berne TV, Demetriades D. Hemodynamic and oxygen transport patterns after head trauma and brain death: implications for management of the organ donor. J Trauma. 2007 Nov; 63(5):1032-42. PMID: 17993948
- Dang AC, Warren AP, Kim HT. Beneficial effects of intra-articular caspase inhibition therapy following osteochondral injury. Osteoarthritis Cartilage. 2006 Jun; 14(6):526-32. PMID: 16483806
- Nicholls TP, Shoemaker WC, Wo CC, Gruen JP, Amar A, Dang AB. Survival, hemodynamics, and tissue oxygenation after head trauma. J Am Coll Surg. 2006 Jan; 202(1):120-30. PMID: 16377505
- Costouros JG, Dang AC, Kim HT. Comparison of chondrocyte apoptosis in vivo and in vitro following acute osteochondral injury. J Orthop Res. 2004 May; 22(3):678-83. PMID: 15099652
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About Alexis Dang, MD
My professional interests and goals lie in one simple principle: to improve the lives of my patients. For me, this must be achieved not only with outstanding technical skill but also with knowledge and application of the basic science that underlies pathology. As an orthopaedic surgeon, I am excited by the prospect of restoring function to patients who suffer from traumatic cartilage injury. These are often patients who have much to gain and much to contribute after proper restoration. As a musculoskeletal research scientist, I understand that restoration must incorporate treatment at the functional level of the individual as well as at the cellular and molecular levels.
As a surgeon at the San Francisco VA, care for our veterans inevitably involves orthopaedics, many battlefield injuries involve joint damage leading to post-traumatic osteoarthritis (PTOA). This is a condition that disproportionately affects our aging veterans as compared to the general population. My research goal is to deeply understand the molecular, cellular, and genetic processes that underlie the transition from acute joint injury to PTOA, in order to develop effective treatment strategies. In orthopaedics, post-traumatic care involves much more than treatment of the acute injury, because the consequences of acute or repetitive injury often do not present until much later in life. To this end and to develop effective treatments, an understanding of which mechanisms are set in motion at the time of injury and during the development of PTOA is essential.
My research background puts me in a unique position to study these mechanisms. My clinical background allows me to appreciate the importance and intricacies of this clinical issue. I have significant experience with small animal models of musculoskeletal injury, including the development and refinement of a articular injury model for post-traumatic osteoarthritis.