Alfred Kuo, MD, PhD

Alfred Kuo, MD, PhD

Alfred Kuo, MD, PhD

Professor

Arthritis & Joint Replacement

VA Hospital - Arthritis & Joint Replacement

4150 Clement Street
San Francisco CA 94121

415-221-4810
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Publications

Su F, Cogan CJ, Bendich I, Zhang N, Whooley MA, Kuo AC. Hepatitis C infection and complication rates after total shoulder arthroplasty in United States veterans. JSES Int. 2021 Jul; 5(4):699-706. PMID: 34223418

Bendich I, Zhang N, Barry JJ, Ward DT, Whooley MA, Kuo AC. Antibiotic-Laden Bone Cement Use and Revision Risk After Primary Total Knee Arthroplasty in U.S. Veterans. J Bone Joint Surg Am. 2020 Nov 18; 102(22):1939-1947. PMID: 32890041

Harris AHS, Kuo AC, Bowe TR, Manfredi L, Lalani NF, Giori NJ. Can Machine Learning Methods Produce Accurate and Easy-to-Use Preoperative Prediction Models of One-Year Improvements in Pain and Functioning After Knee Arthroplasty? J Arthroplasty. 2021 01; 36(1):112-117.e6. PMID: 32798181

Rubenstein WJ, Harris AHS, Hwang KM, Giori NJ, Kuo AC. Social Determinants of Health and Patient-Reported Outcomes Following Total Hip and Knee Arthroplasty in Veterans. J Arthroplasty. 2020 09; 35(9):2357-2362. PMID: 32498969

Kuo AC, Giori NJ, Bowe TR, Manfredi L, Lalani NF, Nordin DA, Harris AHS. Comparing Methods to Determine the Minimal Clinically Important Differences in Patient-Reported Outcome Measures for Veterans Undergoing Elective Total Hip or Knee Arthroplasty in Veterans Health Administration Hospitals. JAMA Surg. 2020 05 01; 155(5):404-411. PMID: 32211842

Ward DT, Grotkopp E, Detch RC, Kim HT, Kuo AC. Comparison of Periarticular Infiltration and Combination Delivery of Local Anesthetics for Reducing Pain and Opioid Consumption after Total Knee Arthroplasty. J Knee Surg. 2021 Sep; 34(11):1149-1154. PMID: 32143218

Patterson JT, Takemoto SK, Shearer DW, Kuo AC. Does Implant Choice Affect the Episode Cost of Pertrochanteric Hip Fracture for US Veterans? J Orthop Trauma. 2019 Dec; 33(12):635-641. PMID: 31425414

Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T. Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. Bone Res. 2019; 7:34. PMID: 31700695

Bendich I, Takemoto S, Patterson JT, Monto A, Barber TC, Kuo AC. Preoperative Treatment of Hepatitis C Is Associated With Lower Prosthetic Joint Infection Rates in US Veterans. J Arthroplasty. 2019 Jul; 34(7S):S319-S326.e1. PMID: 30930157

Harris AHS, Kuo AC, Weng Y, Trickey AW, Bowe T, Giori NJ. Can Machine Learning Methods Produce Accurate and Easy-to-use Prediction Models of 30-day Complications and Mortality After Knee or Hip Arthroplasty? Clin Orthop Relat Res. 2019 02; 477(2):452-460. PMID: 30624314

Kuo AC, Raghunathan K, Lartigue AM, Bryan WE, Pepin MJ, Takemoto S, Wallace AW. Freedom From Opioids After Total Knee Arthroplasty. J Arthroplasty. 2019 05; 34(5):893-897. PMID: 30777627

Dang ABC, Hong H, Lee K, Luan T, Reddy S, Kuo AC. Repurposing Human Osteoarthritic Cartilage as a Bone Graft Substitute in an Athymic Rat Posterolateral Spinal Fusion Model. Int J Spine Surg. 2018 Dec; 12(6):735-742. PMID: 30619678

Hsia HL, Takemoto S, van de Ven T, Pyati S, Buchheit T, Ray N, Wellman S, Kuo A, Wallace A, Raghunathan K. Acute Pain Is Associated With Chronic Opioid Use After Total Knee Arthroplasty. Reg Anesth Pain Med. 2018 Oct; 43(7):705-711. PMID: 29975257

Harris AHS, Kuo AC, Bozic KJ, Lau E, Bowe T, Gupta S, Giori NJ. American Joint Replacement Registry Risk Calculator Does Not Predict 90-day Mortality in Veterans Undergoing Total Joint Replacement. Clin Orthop Relat Res. 2018 09; 476(9):1869-1875. PMID: 30113939

Harris AH, Kuo AC, Bowe T, Gupta S, Nordin D, Giori NJ. Prediction Models for 30-Day Mortality and Complications After Total Knee and Hip Arthroplasties for Veteran Health Administration Patients With Osteoarthritis. J Arthroplasty. 2018 05; 33(5):1539-1545. PMID: 29398261

Kuo AC, Grotkopp E. A Simple Method Associated With Reduced Opioid Consumption After Total Knee Arthroplasty. J Arthroplasty. 2017 10; 32(10):3034-3037. PMID: 28634091

Chu S, Chen N, Dang ABC, Kuo AC, Dang ABC. The Effects of Topical Vancomycin on Mesenchymal Stem Cells: More May Not Be Better. Int J Spine Surg. 2017; 11:12. PMID: 28765796

Lu M, Sing DC, Kuo AC, Hansen EN. Preoperative Anemia Independently Predicts 30-Day Complications After Aseptic and Septic Revision Total Joint Arthroplasty. J Arthroplasty. 2017 09; 32(9S):S197-S201. PMID: 28390884

Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC. Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Tissue Eng Part A. 2016 Mar; 22(5-6):427-35. PMID: 26830207

Krigbaum H, Takemoto S, Kim HT, Kuo AC. Costs and Complications of Short Versus Long Cephalomedullary Nailing of OTA 31-A2 Proximal Femur Fractures in U.S. Veterans. J Orthop Trauma. 2016 Mar; 30(3):125-9. PMID: 26894639

Ward DT, Metz LN, Horst PK, Kim HT, Kuo AC. Complications of Morbid Obesity in Total Joint Arthroplasty: Risk Stratification Based on BMI. J Arthroplasty. 2015 Sep; 30(9 Suppl):42-6. PMID: 26117070

Wang M, Rahnama R, Cheng T, Grotkopp E, Jacobs L, Limburg S, Kim HT, Kuo AC. Trophic stimulation of articular chondrocytes by late-passage mesenchymal stem cells in coculture. J Orthop Res. 2013 Dec; 31(12):1936-42. PMID: 24038580

Lin CA, Takemoto S, Kandemir U, Kuo AC. Mid-term outcomes in HIV-positive patients after primary total hip or knee arthroplasty. J Arthroplasty. 2014 Feb; 29(2):277-82. PMID: 23867663

Jin J, Limburg S, Joshi SK, Landman R, Park M, Zhang Q, Kim HT, Kuo AC. Peripheral nerve repair in rats using composite hydrogel-filled aligned nanofiber conduits with incorporated nerve growth factor. Tissue Eng Part A. 2013 Oct; 19(19-20):2138-46. PMID: 23659607

Lin CA, Kuo AC, Takemoto S. Comorbidities and perioperative complications in HIV-positive patients undergoing primary total hip and knee arthroplasty. J Bone Joint Surg Am. 2013 Jun 05; 95(11):1028-36. PMID: 23780541

Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC. Cytotoxicity of local anesthetics on human mesenchymal stem cells. J Bone Joint Surg Am. 2013 Jan 16; 95(2):132-7. PMID: 23324960

Jin J, Park M, Rengarajan A, Zhang Q, Limburg S, Joshi SK, Patel S, Kim HT, Kuo AC. Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model. Regen Med. 2012 Nov; 7(6):799-806. PMID: 23164080

Cheng T, Yang C, Weber N, Kim HT, Kuo AC. Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis. Biochem Biophys Res Commun. 2012 Oct 05; 426(4):544-50. PMID: 22982316

Piper SL, Wang M, Yamamoto A, Malek F, Luu A, Kuo AC, Kim HT. Inducible immortality in hTERT-human mesenchymal stem cells. J Orthop Res. 2012 Dec; 30(12):1879-85. PMID: 22674533

Cheng T, Maddox NC, Wong AW, Rahnama R, Kuo AC. Comparison of gene expression patterns in articular cartilage and dedifferentiated articular chondrocytes. J Orthop Res. 2012 Feb; 30(2):234-45. PMID: 21809379

Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011 Oct; 19(10):1210-8. PMID: 21816228

Tang SY, Mathews P, Randall C, Yurtsev E, Fields K, Wong A, Kuo A, Alliston T, Hansma P. In situ Materials Characterization using the Tissue Diagnostic Instrument. Polym Test. 2010 Apr 01; 29(2):159-163. PMID: 20582333

Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J. The tissue diagnostic instrument. Rev Sci Instrum. 2009 May; 80(5):054303. PMID: 19485522

Kuo A, Ezzet KA, Patil S, Colwell CW. Total hip arthroplasty in rapidly destructive osteoarthritis of the hip: a case series. HSS J. 2009 Sep; 5(2):117-9. PMID: 19308645

Kuo AC, Rodrigo JJ, Reddi AH, Curtiss S, Grotkopp E, Chiu M. Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repair. Osteoarthritis Cartilage. 2006 Nov; 14(11):1126-35. PMID: 16765606

Kuo AC, Meehan JP, Lee M. Knee fusion using dual platings with the locking compression plate. J Arthroplasty. 2005 Sep; 20(6):772-6. PMID: 16139715

Kuo A, Zhong C, Lane WS, Derynck R. Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55. EMBO J. 2000 Dec 01; 19(23):6427-39. PMID: 11101516

Shum L, Reeves SA, Kuo AC, Fromer ES, Derynck R. Association of the transmembrane TGF-alpha precursor with a protein kinase complex. J Cell Biol. 1994 May; 125(4):903-16. PMID: 8188754

Hu DA, Hu JB, Lee A, Rubenstein WJ, Hwang KM, Ibrahim SA, Kuo AC. What Factors Lead to Racial Disparities in Outcomes After Total Knee Arthroplasty? J Racial Ethn Health Disparities. 2022 Dec; 9(6):2317-2322. PMID: 34642904

Harris AHS, Trickey AW, Eddington HS, Seib CD, Kamal RN, Kuo AC, Ding Q, Giori NJ. A Tool to Estimate Risk of 30-day Mortality and Complications After Hip Fracture Surgery: Accurate Enough for Some but Not All Purposes? A Study From the ACS-NSQIP Database. Clin Orthop Relat Res. 2022 12 01; 480(12):2335-2346. PMID: 35901441

Grants & Awards

Development and Validation of a Risk Calculator for Total Joint Replacement
2015-02-01 - 2020-09-30
NIH I01HX001260
Role: Principal Investigator

Education

		University of California	2019
	M.D.	University of California, San Francisco	2000
	Ph.D.	University of California, San Francisco	1997

About Alfred Kuo, MD, PhD

Alfred Kuo graduated from the University of California, Berkeley with a degree in biochemistry, and then went on to receive a PhD in biochemistry and his medical degree at UCSF as part of the Medical Scientist Training Program. He was a resident in orthopaedic surgery and a research fellow at the University of California, Davis before completing a fellowship in lower extremity reconstruction at the Scripps Clinic in San Diego.

Kuo has received numerous awards and has published papers in Osteoarthritis and Cartilage, the Journal of Arthroplasty and the Journal of Cell Biology. Here at UCSF, he works closely with Hubert Kim, MD, PhD at San Francisco Veterans Medical Center, attends surgery and clinic at San Francisco General Hospital and continues his basic research.

Alfred Kuo graduated from the University of California, Berkeley with a degree in biochemistry, and then went on to receive a PhD in biochemistry and his medical degree at UCSF as part of the Medical Scientist Training Program. He was a resident in orthopaedic surgery and a research fellow at the University of California, Davis before completing a fellowship in lower extremity reconstruction at the Scripps Clinic in San Diego.

Kuo has received numerous awards and has published papers in Osteoarthritis and Cartilage, the Journal of Arthroplasty and the Journal of Cell Biology. Here at UCSF, he works closely with Hubert Kim, MD, PhD at San Francisco Veterans Medical Center, attends surgery and clinic at San Francisco General Hospital and continues his basic research.

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