Andrew Brack, PhD

Andrew Brack, PhD
Parnassus Heights - Brack Lab
35 Medical Center Way
San Francisco CA 94143
415-502-0515
San Francisco CA 94143
Publications
- Hwang AB, Brack AS. Muscle Stem Cells and Aging. Curr Top Dev Biol. 2018; 126:299-322. PMID: 29305003
- Eliazer S, Brack AS. Stem cells: Cause and consequence in aged-muscle decline. Nature. 2016 12 15; 540(7633):349-350. PMID: 27919069
- Brack AS. Pax7 is back. Skelet Muscle. 2014; 4(1):24. PMID: 25546147
- Jung Y, Brack AS. Cellular mechanisms of somatic stem cell aging. Curr Top Dev Biol. 2014; 107:405-38. PMID: 24439814
- Brack AS, Hochedlinger K. ISSCR 2013: back to Bean Town. Stem Cell Reports. 2013; 1(6):479-85. PMID: 25847520
- Brack AS. Ageing of the heart reversed by youthful systemic factors! EMBO J. 2013 Aug 14; 32(16):2189-90. PMID: 23860129
- Brack A. Adult muscle stem cells avoid death and Paxes. Cell Stem Cell. 2009 Aug 07; 5(2):132-4. PMID: 19664985
Grants & Awards
- Niche Regulation of Muscle Stem Cells
2019-08-01 - 2024-05-31
NIH R01AR076252
Role: Principal Investigator
- Single cell activation dynamics as a predictor and regulator of aged MuSC dysfunction.
2019-02-01 - 2021-01-31
NIH R21AG063416
Role: Principal Investigator
- Muscle stem cell heterogeneity
2011-09-21 - 2019-08-31
NIH R56AR060868
Role: Principal Investigator
- Quiescence of Muscle Stem Cells During Growth and Repair
2012-04-01 - 2018-03-31
NIH R01AR061002
Role: Principal Investigator
- Muscle Satellite Cell Pool During Aging
2011-09-21 - 2017-07-31
NIH R01AR060868
Role: Principal Investigator
- The role of P16Ink4a in adult skeletal muscle stem cells
2021-08-17 - 2026-05-31
NIH R01AR079244
Role: Principal Investigator
About Andrew Brack, PhD
Originally from Liverpool, England, Andrew graduated with a PhD in Molecular Biology and Biophysics from King’s College London. He did two postdoctoral fellowships, the first with Simon Hughes at King’s College London and the second with Tom Rando at Stanford University. Andrew started his own lab at the Center for Regenerative Medicine, MGH, Harvard University in 2008. In 2015 he moved to UCSF to begin the next phase of his lab's journey.
Brack Lab's is focused on understanding the cellullar communication between the muscle stem cell and its environment to identify strategies that improve skeletal muscle regeneration and ameliorate sarcopenia.
Quiescence and self-renewal
Maintenance and reacquisition of quiescence are defining features of adult stem cells. We are studying the intrinsic and extrinsic factors that control quiescence and how they impinge on self-renewal and differentiation potential during muscle homeostasis, injury response and aging. Using a muscle stem cell specific mutant we demonstrated that Sprouty1 (Spry1), an RTK signaling inhibitor, is required for the reestablishment of quiescence in proliferating stem cells. We are presently identifying intrinsic and niche-derived signals that promote and retain stem cell potential.
Stem cell niche
The stem cell niche as originally conceptualized refers to the microenvironment that maintains ‘stemness’. The niche is a protector of stem cell number and function restraining proliferation and differentiation of stem cells and maintaining a quiescent phenotype. The satellite cell niche may be composed of different cell types. We are presently identifying the cell types and the essential signaling elements that compose the niche to retain stemness after injury and are deregulated during aging.
Satellite cell heterogeneity
It is apparent that adult stem cell populations are heterogeneous. Using a marker of proliferative history, based on retention of a fluorescent marker, we recently demonstrated that the adult satellite cell pool is composed of subsets of cells that are slowly dividing during ontogeny. Label retaining cells possess the properties of stem cells; in contrast, satellite cell subsets that diluted label functioned as progenitors. During aging a subset of functional label retaining cells are preserved. Current projects are deciphering whether heterogeneity is due to extrinsic influences, such as discrete niches, or cell intrinsic regulation, such as epigenetic and metabolic status.
Aging
Aging is associated with a progressive decline in many tissues throughout the body. Skeletal muscle is no exception. We are studying the mechanisms that lead to a loss of stem cell number and function during aging.
Brack Lab's Full Address is:
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
Department of Orthopaedic Surgery
University of California, San Francisco
35 Medical Center Way Box 0669
San Francisco, CA 94143