Tamara Alliston, PhD

Tamara Alliston, PhD
Professor
Basic Science
Parnassus Heights - Alliston Lab
Education
Publications
- Rys JP, Monteiro DA, Alliston T. Mechanobiology of TGFß signaling in the skeleton. Matrix Biol. 2016 May-Jul; 52-54:413-425. PMID: 26877077
- Nguyen J, Alliston T. Calluses flex their muscles to align bone fragments during fracture repair. Dev Cell. 2014 Oct 27; 31(2):137-8. PMID: 25373771
- Alliston T. Biological regulation of bone quality. Curr Osteoporos Rep. 2014 Sep; 12(3):366-75. PMID: 24894149
- Tang SY, Alliston T. Regulation of postnatal bone homeostasis by TGFß. Bonekey Rep. 2013 Jan 09; 2:255. PMID: 24404376
- Butcher DT, Alliston T, Weaver VM. A tense situation: forcing tumour progression. Nat Rev Cancer. 2009 Feb; 9(2):108-22. PMID: 19165226
Grants & Awards
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2018 Musculoskeletal Biology and Bioengineering Gordon Research Conference and Gordon Research Seminar
March 23, 2018 - February 28, 2019
NIH/NIAMS R13AR073652
Role: Principal Investigator
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miRNA coordination of TGF-beta / Wnt signaling in osteocyte mechanotransduction
August 1, 2017 - July 31, 2019
NIH/NIAMS R21AR070403
Role: Principal Investigator
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AAOS/ORS Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone Research Symposium
September 21, 2015 - August 31, 2016
NIH/NIAMS R13AR068913
Role: Principal Investigator
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The mechanobiology of TGF-beta signaling in chondrocytes
September 18, 2014 - August 31, 2016
NIH/NIAMS R21AR067439
Role: Principal Investigator
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The mechanistic control of bone extracellular matrix material properties by TGFb
July 1, 2008 - July 31, 2019
NIH/NIDCR R01DE019284
Role: Principal Investigator
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TGF-Beta regulation of Runx2 in bone formation and quality
March 1, 2006 - February 28, 2009
NIH/NIDCR R03DE016868
Role: Principal Investigator
Membership & Committees
About Tamara Alliston, PhD
Our research focuses on the mechanobiologic pathways controlling stem cell and skeletal cell differentiation in bone and cartilage. We seek to understand how these pathways maintain the mechanical integrity of the healthy skeleton, and how this is disrupted in skeletal diseases like arthritis and osteoporosis.
In particular, we study the mechanobiology of TGFß in the skeleton. To answer these questions we combine molecular, cellular, physiologic, bioengineering, and materials science approaches. This interdisciplinary approach will advance the development of therapies that can prevent skeletal disease and improve the speed and success of skeletal tissue regeneration.