UCSF Department of Orthopaedic Surgery

Chelsea Bahney, PhD

Assistant Professor

Basic Science

Orthopaedic Trauma Institute - Bahney Lab - Orthopaedic Trauma Institute - Bahney Lab

2550 23rd Street
San Francisco, CA 94110
415-206-8812
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Education

Post-Doctoral Fellowship	University of California, San Francisco	04/2014
PhD	Oregon Health & Science University	08/2010
	Valleylab (now Medtronic)	08/2005
BS	University of Colorado	06/2001

Publications

Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley J, Ahn J, Miclau T, Marcucio R, Hankenson KD. The Cellular Biology of Fracture Healing. J Orthop Res. 2018 Oct 28. PMID: 30370699

Bragdon BC, Bahney CS. Origin of Reparative Stem Cells in Fracture Healing. Curr Osteoporos Rep. 2018 Aug; 16(4):490-503. PMID: 29959723

Wong SA, Rivera KO, Miclau T, Alsberg E, Marcucio RS, Bahney CS. Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering. Front Bioeng Biotechnol. 2018; 6:58. PMID: 29868574

Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA. A degradation fragment of type X collagen is a real-time marker for bone growth velocity. Sci Transl Med. 2017 Dec 06; 9(419). PMID: 29212713

Lin MC, Hu D, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. Using impedance to track fracture healing rates in mice in vivo: A pilot study. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:1724-1727. PMID: 29060219

Lin MC, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. New opportunities for fracture healing detection: Impedance spectroscopy measurements correlate to tissue composition in fractures. J Orthop Res. 2017 12; 35(12):2620-2629. PMID: 28383765

MacBarb RF, Lindsey DP, Bahney CS, Woods SA, Wolfe ML, Yerby SA. Fortifying the Bone-Implant Interface Part 1: An In Vitro Evaluation of 3D-Printed and TPS Porous Surfaces. Int J Spine Surg. 2017; 11:15. PMID: 28765799

Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T. Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing? Front Cell Dev Biol. 2017; 5:45. PMID: 28523266

Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 01 15; 144(2):221-234. PMID: 28096214

Bahney CS, Bruder SP, Cain JD, Keyak JH, Killian ML, Shapiro IM, Jones LC. Accelerating the pace of discovery in orthopaedic research: A vision toward team science. J Orthop Res. 2016 10; 34(10):1673-1679. PMID: 27219218

Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC. Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Tissue Eng Part A. 2016 Mar; 22(5-6):427-35. PMID: 26830207

Giannoudis PV, Hak D, Sanders D, Donohoe E, Tosounidis T, Bahney C. Inflammation, Bone Healing, and Anti-Inflammatory Drugs: An Update. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S6-9. PMID: 26584270

Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T. Stem Cell Therapies in Orthopaedic Trauma. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S24-7. PMID: 26584262

Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C. Tissue engineering strategies for promoting vascularized bone regeneration. Bone. 2016 Feb; 83:197-209. PMID: 26608518

Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S. The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells. Acta Biomater. 2015 May; 18:100-11. PMID: 25735800

Bahney, CS; Hu, DP; Miclau, T; Marcucio, RS. Review Article. The multifaceted role of the vasculature in endochondral fracture repair. 2015.

Bahney CS, Hu DP, Miclau T, Marcucio RS. The multifaceted role of the vasculature in endochondral fracture repair. Front Endocrinol (Lausanne). 2015; 6:4. PMID: 25699016

Lin MC, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. Impedance spectroscopy to monitor fracture healing. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:5138-41. PMID: 26737448

Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS. Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation. J Bone Miner Res. 2014; 29(5):1269-82. PMID: 24259230

Yu YY, Bahney C, Hu D, Marcucio RS, Miclau T. Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects. J Vis Exp. 2012 Apr 11; (62). PMID: 22525683

Bahney CS, Miclau T. Therapeutic potential of stem cells in orthopedics. Indian J Orthop. 2012 Jan; 46(1):4-9. PMID: 22345800

Bahney CS, Lujan TJ, Hsu CW, Bottlang M, West JL, Johnstone B. Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels. Eur Cell Mater. 2011 Jul 15; 22:43-55; discussion 55. PMID: 21761391

Bahney CS, Hsu CW, Yoo JU, West JL, Johnstone B. A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells. FASEB J. 2011 May; 25(5):1486-96. PMID: 21282205

Lujan TJ, Wirtz KM, Bahney CS, Madey SM, Johnstone B, Bottlang M. A novel bioreactor for the dynamic stimulation and mechanical evaluation of multiple tissue-engineered constructs. Tissue Eng Part C Methods. 2011 Mar; 17(3):367-74. PMID: 20950252

Buxton AN, Bahney CS, Yoo JU, Johnstone B. Temporal exposure to chondrogenic factors modulates human mesenchymal stem cell chondrogenesis in hydrogels. Tissue Eng Part A. 2011 Feb; 17(3-4):371-80. PMID: 20799905

Grants & Awards

, Bimodal therapeutic application of LIF for regulating chondrogenic fate,
, Promoting vascularized bone regeneration with endochondral cartilage grafts,
, A Murine Model of Polytrauma: Understanding the molecular basis of accelerated bone repair with concomitant traumatic brain injury.,
, Tissue engineering application of endochondral ossification for bone regeneration,
, Innervation during fracture repair: exploring functional mechanisms and innovative therapeutic repair strategies.,
, OsteoNova: Tissue Engineering Approach to Translating Endochondral Bone Regeneration,
, Development of a Novel Impedance Sensor to Monitor Fracture Healing,

Membership & Committees

About Chelsea Bahney, PhD

The overall goal of my research is to develop novel therapies for the treatment of musculoskeletal diseases and injuries. Specifically, I believe we can drive improved tissue regeneration by recapitulating the normal sequences of development and repair. To accomplish this “Developmental Engineering” approach our laboratory utilizes a cross-disciplinary tools combining biologically modified synthetic polymers, stem cell biology, and murine models of orthopaedic injuries. The long-term goal of our research is to solve problems that will have a direct and significant impact on human health.

Current Projects:

(1) Tissue engineering strategies to promote endochondral bone regeneration
(2) Transdifferentiation of cartilage to bone during fracture repair and osteoarthritis
(3) The role of the nerve in fracture repair
(4) Polytraumatic Injuries: How brain trauma influences fracture healing
(5) Impedance sensors to monitor fracture healing